Related Experiment Video
Updated: Mar 30, 2026
06:42
Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
Published on: September 2, 2025
736
[Exploring a non-inflammatory clinical breast mass: Clinical practice guidelines]
G Legendre1, N Guilhen2, C Nadeau2
1Service de gynécologie-obstétrique, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 01, France; CESP-Inserm, U1018, équipe 7, genre, santé sexuelle et reproductive, université Paris Sud, 94276 Le Kremlin-Bicêtre, France.
Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|November 7, 2015
Summary
Physical examination alone is insufficient for diagnosing breast masses. Combining mammography and ultrasound offers high accuracy in excluding breast cancer, guiding diagnostic recommendations.
Area of Science:
- Radiology
- Oncology
- Diagnostic Imaging
Background:
- Palpable breast masses are common clinical findings.
- Accurate diagnosis is crucial for timely breast cancer detection and management.
Purpose of the Study:
- To evaluate the diagnostic utility of physical examination, imaging, and biopsy for non-inflammatory palpable breast masses.
- To establish evidence-based guidelines for breast mass evaluation.
Main Methods:
- Systematic literature review of Medline and Cochrane databases.
- Consultation of international clinical guidelines (French and English).
- Data analysis focused on diagnostic accuracy and evidence levels.
Main Results:
- Physical examination alone cannot rule out breast cancer.
- Mammography sensitivity ranges from 70-95%; ultrasound sensitivity is 98-100%.
- Core needle biopsy outperforms fine-needle aspiration for diagnostic accuracy. Combined mammography and ultrasound show excellent sensitivity and negative predictive value.
Conclusions:
- A combined approach of mammography and ultrasound is recommended for palpable breast masses.
- This dual imaging strategy effectively excludes breast cancer, improving diagnostic confidence.
- Guidelines support integrated imaging for non-inflammatory palpable breast masses.
