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Updated: Mar 30, 2026
A Heterotopic Mouse Model for Studying Laryngeal Transplantation
Published on: January 13, 2023
Staged laryngeal reconstruction with a prefabricated flap for radiation recurrent glottic carcinoma
Moustafa W Mourad1, Henry K Su2, Jerry R Castro1,2
1Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Beth Israel, New York, New York, U.S.A.
Objectives/Hypothesis:
Although salvage total laryngectomy remains the definitive approach to recurrent/persistent glottic cancer following failed radiation therapy for favorable early-stage disease, it comes at the price of a permanent laryngostome and an impact on quality of life. We describe a three-stage method of laryngeal reconstruction for salvage partial laryngectomy to address the unique challenges of operating on radiation recurrent/persistent cancer.
Study Design:
This was a single-surgeon retrospective case series of patients who underwent a three-stage laryngeal reconstruction for salvage partial laryngectomy.
Methods:
We performed a comprehensive review of the clinical, pathologic, and radiologic files of all patients who underwent a three-stage laryngeal reconstruction for salvage partial laryngectomy.
Results:
Seven male patients underwent a three-stage laryngeal reconstruction following open partial salvage laryngectomy. The average follow-up time since salvage surgery was 55 months. All patients were without evidence of recurrence and demonstrated satisfactory functional outcomes.
Conclusion:
Staged reconstruction provides a more controlled assessment of wound healing and valuable pathologic information regarding the specific disease virulence and adequacy of the margins.
Level Of Evidence:
4. Laryngoscope, 126:1061-1070, 2016.
