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Disorders of the Female Reproductive System01:24

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Related Experiment Videos

Malignancies in pregnancy.

Catherine M Albright1, Katharine D Wenstrom1

  • 1Division of Maternal Fetal Medicine, Brown University, Women and Infants Hospital, 101 Dudley Street, Providence, RI 02905, USA.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|November 7, 2015
PubMed
Summary
This summary is machine-generated.

Malignancy in pregnancy is rare but requires careful management. Treatment balances maternal benefit and fetal safety, with surgery and chemotherapy generally safe options.

Keywords:
chemotherapyneoplasmspregnancyradiation therapy

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Area of Science:

  • Obstetrics and Gynecology
  • Oncology

Background:

  • Malignancy complicating pregnancy affects 1 in 1000 to 1500 pregnancies.
  • Optimal management necessitates balancing maternal treatment benefits against fetal harm.

Purpose of the Study:

  • To provide obstetricians with an overview of diagnosing and managing cancer during pregnancy.
  • To highlight key considerations for multidisciplinary care.

Main Methods:

  • This is a review article.
  • It synthesizes current knowledge on cancer in pregnancy.

Main Results:

  • Surgery and chemotherapy are generally safe during pregnancy.
  • Radiation therapy is relatively contraindicated.
  • Iatrogenic prematurity is a common complication due to early delivery for maternal benefit.

Conclusions:

  • Survival rates for pregnant patients with cancer are comparable to the nonpregnant population.
  • Management requires a multidisciplinary team experienced in complex cases.
  • Careful consideration of disease extent, treatment, and gestational age is crucial.