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Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Structure and Function of Platelets01:18

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
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Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Related Experiment Video

Updated: Mar 30, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Interaction between circulating cancer cells and platelets: clinical implication.

Xiao-Liang Lou1, Jian Sun1, Shu-Qi Gong1

  • 11 Molecular Medicine and Genetics Center, 2 Department of Pathology, The Fourth Affiliated Hospital of Nanchang University, Nanchang 330000, China ; 3 Renmin Institute of Forensic Medicine, Nanchang 330000, China.

Chinese Journal of Cancer Research = Chung-Kuo Yen Cheng Yen Chiu
|November 7, 2015
PubMed
Summary
This summary is machine-generated.

Platelets play a crucial role in cancer metastasis by aiding circulating tumor cells (CTCs) to detach, survive, and spread. Understanding these platelet-cancer cell interactions can inform new therapies to reduce cancer spread.

Keywords:
Circulating tumor cells (CTCs)epithelial-mesenchymal transition (EMT)immune surveillancemetastasisplatelet

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Microfluidics in Assessing Platelet Function
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Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
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Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
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Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

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Area of Science:

  • Oncology
  • Hematology
  • Cell Biology

Background:

  • Metastasis, the spread of cancer, is the primary cause of cancer-related deaths.
  • Thrombocytosis (elevated platelet count) is common in metastatic cancer patients, indicating platelets' involvement.
  • Circulating tumor cells (CTCs) are key players in the metastatic process.

Purpose of the Study:

  • To review the multifaceted roles of platelets in facilitating cancer metastasis.
  • To elucidate how platelets support circulating tumor cells (CTCs) during metastasis.
  • To explore potential therapeutic strategies targeting platelet-cancer cell interactions.

Main Methods:

  • Literature review focusing on the interaction between platelets and circulating tumor cells (CTCs).
  • Analysis of mechanisms by which platelets influence CTC generation, protection, and extravasation.
  • Examination of the role of platelet-derived factors in metastasis.

Main Results:

  • Platelets facilitate CTC detachment from primary tumors.
  • Platelets protect CTCs from immune surveillance, apoptosis, and mechanical stress.
  • Platelets regulate the intravasation and extravasation of CTCs at metastatic sites.
  • Platelet-derived cytokines and receptors are integral to these processes.

Conclusions:

  • Platelets are critical facilitators of cancer metastasis.
  • Targeting platelet-CTCs interactions offers a promising therapeutic avenue to inhibit metastasis.
  • Further research into these mechanisms could lead to novel anti-metastatic treatments.