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Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes

Srilalitha Kuruganti1, Shane Miersch2, Ashlesha Deshpande1

  • 1From the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294.

The Journal of Biological Chemistry
|November 8, 2015
PubMed
Summary

Researchers created antibody-based activators of cytokine signaling (AcCS) to boost natural type I interferons (IFNs) activity. This approach enhances antiviral potency while minimizing toxicity, offering a potential therapeutic alternative.

Keywords:
cell signalingconformational changecytokineinterferonphage displayprotein structurereceptor

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