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Rapid adipose deposition with mood disorders.

Jess G Fiedorowicz¹, Lorick E Andersen, Jane E Persons

¹Department of Psychiatry, Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA USA, Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA USA.

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists

|November 12, 2015

Summary

This summary is machine-generated.

Persons with bipolar disorder gain significant body fat during mood episodes. This suggests obesity prevention efforts should target acute symptom exacerbations in bipolar disorder patients.

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Area of Science:

Metabolic health in psychiatric disorders
Obesity and body composition research

Background:

Bipolar disorder is linked to a high risk of obesity.
The specific timeline of weight gain in bipolar disorder remains unclear.

Purpose of the Study:

To prospectively investigate the time course of fat distribution changes in bipolar disorder.
To examine the relationship between medication exposure, mood symptoms, and adiposity.

Main Methods:

Prospective study of 36 participants with bipolar disorder.
Dual-energy x-ray absorptiometry used to assess fat distribution.
Evaluated changes in adiposity over a 6-month follow-up period.

Main Results:

Participants showed increased adiposity over 6 months (fat mass index, visceral fat area, total percent fat).
Manic symptoms, not antipsychotic medication, correlated with increased adiposity.
Baseline adiposity was linked to age and sex, not past medication or symptom course.

Conclusions:

Acute mood disorder exacerbations are critical periods for fat deposition.
Obesity prevention strategies may be crucial during acute phases of bipolar disorder.