Related Experiment Video
Updated: Mar 30, 2026
09:03
Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
Published on: June 20, 2015
10.5K
Association Between Trabecular Meshwork Anteroposterior Length and Anterior Chamber Angle Width
Roland Y Lee1, Shuai-Chun Lin2, Rebecca I Chen3
1Department of Ophthalmology, University of California, San Francisco, San Francisco, California; Wake Forest University School of Medicine, Winston-Salem, North Carolina.
American Journal of Ophthalmology
|November 12, 2015
Summary
Wider anterior chamber angles are associated with greater trabecular meshwork anteroposterior length in healthy eyes. This finding may inform our understanding of ocular anatomy and angle-related conditions.
Area of Science:
- Ophthalmology
- Anatomy
Background:
- The anterior chamber angle is crucial for aqueous humor outflow.
- Trabecular meshwork anteroposterior length is a key anatomical feature influencing outflow.
- Understanding their relationship is vital for diagnosing and managing angle-related eye conditions.
Purpose of the Study:
- To investigate the association between trabecular meshwork anteroposterior length and anterior chamber angle width.
- To quantify this relationship in a cohort of nonglaucomatous subjects.
Main Methods:
- A prospective, cross-sectional study analyzed optical coherence tomography images from 561 eyes of 366 subjects.
- Trabecular meshwork anteroposterior length and various anterior chamber angle parameters were measured.
- Linear mixed-effect regression models were employed to assess associations, adjusting for covariates.
Main Results:
- A significant positive association was found between trabecular meshwork anteroposterior length and all measured anterior chamber angle width parameters.
- Multivariate analyses confirmed this association, indicating that greater trabecular meshwork anteroposterior length correlates with wider angles.
Conclusions:
- Wider anterior chamber angles are associated with greater trabecular meshwork anteroposterior length in nonglaucomatous individuals.
- This anatomical correlation may have implications for understanding ocular fluid dynamics and susceptibility to angle-closure glaucoma.
More Related Videos
Related Concept Videos
01:28Angle Closure Glaucoma: Treatment
1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
01:25Glaucoma: Overview
1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K
01:27Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K