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Effects of Physical (In)activity on Platelet Function.

Stefan Heber1, Ivo Volf1

  • 1Institute of Physiology-Centre for Physiology & Pharmacology, Medical University of Vienna, Schwarzspanierstraße 17, 1090 Vienna, Austria.

Biomed Research International
|November 12, 2015
PubMed
Summary
This summary is machine-generated.

Regular exercise, particularly at higher intensities, impacts platelet activation. While strenuous exercise can activate platelets, consistent physical activity and fitness reduce this activation, mirroring exercise

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Area of Science:

  • Cardiovascular Science
  • Exercise Physiology
  • Hematology

Background:

  • Platelets are central to cardiovascular disease (CVD) development due to their role in releasing growth factors and inflammatory mediators.
  • Cardiovascular risk factors promote platelet hyperreactivity, and physical activity influences platelet function.
  • Understanding exercise's impact on platelet function is crucial for CVD prevention and management.

Purpose of the Study:

  • To summarize and discuss current knowledge on how acute and habitual exercise affect platelet function.
  • To identify critical determinants influencing the relationship between exercise and platelet activation.
  • To elucidate the similarities between exercise's effects on platelet function and its impact on cardiovascular event risk.

Main Methods:

  • Literature review and analysis of existing studies on exercise and platelet function.
  • Examination of the roles of exercise intensity and cardiorespiratory fitness in modulating platelet responses.
  • Synthesis of findings to establish key conclusions regarding exercise's influence on platelet behavior.

Main Results:

  • Acute, strenuous exercise can lead to platelet activation.
  • Regular physical activity and higher cardiorespiratory fitness attenuate or prevent platelet activation during acute exercise.
  • Habitual physical activity favorably modulates platelet function even at rest.

Conclusions:

  • Exercise intensity and individual fitness levels are critical factors in determining exercise-induced platelet activation.
  • Consistent physical activity offers protective effects by reducing platelet activation, both during exercise and at rest.
  • The modulation of platelet function by exercise parallels the known effects of physical activity on cardiovascular mortality and morbidity.