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Updated: Mar 30, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
Published on: June 8, 2022
Percutaneous Pulmonary Valve Implantation: Present Status and Evolving Future.
Mohammad M Ansari1, Rhanderson Cardoso2, Daniel Garcia2
1Metro Heart and Vascular Institute, Metro Health Hospital, Michigan State University, Wyoming, Michigan.
Percutaneous pulmonary valve implantation (PPVI) offers a safe, effective alternative to surgery for right ventricular outflow tract (RVOT) dysfunction. While improving patient outcomes, anatomical limitations currently restrict PPVI eligibility.
Area of Science:
- Cardiology
- Interventional Cardiology
- Congenital Heart Disease
Background:
- Recurrent right ventricular outflow tract (RVOT) dysfunction necessitates multiple surgeries in complex congenital heart disease patients.
- Dysfunctional surgical RVOT conduits are a common issue requiring intervention.
Purpose of the Study:
- To review contemporary practices, evidence, and future developments in percutaneous pulmonary valve implantation (PPVI).
- To assess PPVI as a nonsurgical alternative for RVOT dysfunction.
Main Methods:
- Review of current literature on percutaneous pulmonary valve implantation (PPVI).
- Analysis of evidence supporting PPVI in patients with dysfunctional RVOT conduits.
Main Results:
- PPVI is a safe and effective procedure for patients with dysfunctional RVOT conduits.
- PPVI can improve symptoms, functional capacity, and biventricular hemodynamics.
- Current anatomical limitations restrict PPVI eligibility to less than 25% of eligible patients.
Conclusions:
- PPVI presents a promising nonsurgical option for RVOT dysfunction.
- Future technologies may expand PPVI eligibility and applications.
- Further research is needed to overcome current anatomical limitations for broader PPVI use.
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