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A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
Published on: January 12, 2017
Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A
Arturo Domínguez1, Miquel Bayó2, Jesús Muñoz-Rodríguez1
1Urology Department, Institut Català dUrologia i Nefrologia, Barcelona, Spain.
Abstract:
Heterophilic antibodies are human immunoglobulins directed against various animal antigens. They can produce false-positive results in the analysis of different tumor markers, including prostate-specific antigen. This interference can lead to misdiagnosis, unnecessary tests, and overtreatment in some cases. We present herein the case of a 52-year-old man with repeated spurious elevation of prostate-specific antigen, reaching levels of 108.7 ng/mL, that were suspected to be caused by heterophilic antibodies. The interference was solved by changing the analysis technique. Real values of prostate-specific antigen were less than 1 ng/mL.
