Cerebral venous thrombosis in a Caribbean population
1Emergency Unit, University Hospital of Pointe-à-Pitre, route de Chauvel, 97139 Pointe-à-Pitre, Guadeloupe.
Revue Neurologique
|November 18, 2015
Summary
Cerebral venous thrombosis (CVT) is more common in Guadeloupe than in Western countries, particularly affecting young women. Protein S deficit is a frequent cause of thrombophilia in this population.
Area of Science:
- Neurology
- Vascular Medicine
- Epidemiology
Background:
- Cerebral venous thrombosis (CVT) presents diverse clinical and etiological profiles.
- Limited data exists on CVT in Black populations.
- This study investigates CVT in Guadeloupe, a Caribbean French Overseas Department.
Purpose of the Study:
- To examine the clinical, radiological, and etiological aspects of CVT in Guadeloupe.
- To assess the outcome of CVT in this population.
- To compare CVT characteristics in Guadeloupe with those in Caucasian populations.
Main Methods:
- Retrospective study of patients hospitalized with CVT between 2000 and 2011.
- Inclusion of 45 patients with confirmed CVT via medical imaging.
- Data collection on patient demographics, clinical presentation, imaging, etiology, and outcome.
Main Results:
- Estimated CVT incidence in Guadeloupe: 15-20 per 100,000 annually.
- Predominantly affected young women (73.3%), average age 40.
- Headaches were the primary symptom (93%); superior sagittal sinus (60%) and lateral sinuses (64.4%) were most affected.
- Oral estro-progestative contraception (40%) and thrombophilia (33.3%) were key etiological factors.
- Protein S deficit was more frequent than in Caucasian populations.
Conclusions:
- CVT clinical and radiological features in Guadeloupe align with global findings.
- Incidence of CVT in Guadeloupe appears higher than in Western countries.
- Protein S deficit is the predominant thrombophilia cause in this population.
- Further research is needed to understand thrombo-embolic risk factors in Black populations.
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