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Updated: Feb 2, 2026
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Acute myelitis associated with dengue infection
A Landais1, B Hartz1, R Alhendi1
1Service de neurologie, CHU de Pointe-à-Pitre, route de Chauvel, 97139 Abymes Guadeloupe, France.
Objectives:
To present a rare neurological complication of dengue fever.
Patients And Methods:
A 24-year-old female presented with acute myelitis seven days after dengue fever onset.
Results:
The patient presented with intense fever. The day-7 examination revealed a paraparesis, T2 sensory level, and urinary retention. The patient complained of electric discharges in the four limbs. The sitting and standing positions were impossible. An MRI of the spinal cord performed on day 8 revealed diffuse medullar hyper intense lesions on T2-weighted sequences at the cervical and thoracic levels, with enhancement of the thoracic lesion after gadolinium injection. Laboratory tests revealed positive dengue antigen on day 5 and positive IgM/IgG on day 8. Treatment with intravenous pulse methylprednisolone was initiated.
Conclusion:
Dengue virus has not often been reported as a cause of myelitis. Physicians must be aware of this rare complication in patients living in or coming from endemic areas.
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