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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
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Acute myelitis associated with dengue infection.
A Landais1, B Hartz1, R Alhendi1
1Service de neurologie, CHU de Pointe-à-Pitre, route de Chauvel, 97139 Abymes Guadeloupe, France.
Medecine Et Maladies Infectieuses
|November 14, 2018
Summary
Dengue fever can cause acute myelitis, a rare neurological condition affecting the spinal cord. Early recognition and treatment are crucial for patients in dengue-endemic regions.
Area of Science:
- Neurology
- Infectious Diseases
- Immunology
Background:
- Dengue fever is a mosquito-borne viral illness endemic in tropical and subtropical regions.
- Neurological complications of dengue, though uncommon, can be severe and varied.
- Myelitis, inflammation of the spinal cord, is a particularly rare manifestation.
Observation:
- A 24-year-old female developed acute myelitis seven days post-dengue fever onset.
- Symptoms included paraparesis, sensory level, urinary retention, and paraesthesia in all limbs.
- Spinal cord MRI revealed diffuse T2 hyperintense lesions with gadolinium enhancement.
Findings:
- Laboratory tests confirmed dengue infection with positive antigen and antibody detection.
- The clinical presentation and MRI findings were consistent with dengue-associated myelitis.
- Intravenous pulse methylprednisolone treatment was initiated.
Implications:
- This case highlights dengue virus as a potential cause of myelitis.
- Physicians should consider dengue-associated myelitis in patients presenting with neurological symptoms in endemic areas.
- Awareness of this rare complication is vital for timely diagnosis and management.
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