Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intrathecal baclofen for severe spinal spasticity.

R D Penn1, S M Savoy, D Corcos

  • 1Department of Neurosurgery, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612.

The New England Journal of Medicine
|June 8, 1989
PubMed
Summary

Intrathecal baclofen infusion effectively reduces muscle tone and spasms in patients with spinal spasticity. This treatment offers long-term relief for those unresponsive to oral baclofen.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to: In Utero Exposure to Anesthetics Alters Neuronal Migration Pattern in Developing Cerebral Cortex and Causes Postnatal Behavioral Deficits in Rats.

Cerebral cortex (New York, N.Y. : 1991)·2020
Same author

In utero Exposure to Anesthetics Alters Neuronal Migration Pattern in Developing Cerebral Cortex and Causes Postnatal Behavioral Deficits in Rats.

Cerebral cortex (New York, N.Y. : 1991)·2019
Same author

Food-Nonfood Discrimination in Ancestral Vertebrates: Gamete Cannibalism and the Origin of the Adaptive Immune System.

Scandinavian journal of immunology·2015
Same author

MRI volumetric studies in Alzheimer's disease: relationship to clinical and neuropsychological variables.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2011
Same author

Peripheral nerve stimulator for the treatment of supraorbital neuralgia: a retrospective case series.

Cephalalgia : an international journal of headache·2008
Same author

Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.

Neurology·2003

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Spinal spasticity, characterized by abnormal muscle tone and spasms, significantly impacts patients with conditions like multiple sclerosis and spinal cord injury.
  • Oral baclofen is a common treatment, but some patients do not respond adequately.

Purpose of the Study:

  • To evaluate the efficacy and safety of intrathecal baclofen infusion as a treatment for spinal spasticity in patients refractory to oral baclofen.

Main Methods:

  • A randomized, double-blind, crossover study involving 20 patients with spinal spasticity.
  • Patients received intrathecal baclofen or saline via an implanted programmable pump for three days.
  • Followed by an open-label, long-term continuous infusion trial.

Main Results:

Related Experiment Videos

  • Significant reductions in muscle tone (Ashworth score) and spasm frequency were observed in all patients.
  • Motor function tests and patient assessments accurately identified baclofen infusion periods.
  • Long-term follow-up demonstrated sustained reduction in spasticity without significant adverse effects like drowsiness or confusion.

    • Conclusions:

    • Intrathecal baclofen is a safe and effective long-term therapy for spinal spasticity unresponsive to oral baclofen.
    • Continuous intrathecal baclofen infusion provides sustained relief and improves quality of life.