The absorption of subcutaneously injected insulin

Insulin has been used for the treatment of diabetes mellitus for 65 years. Still, little is known about the processes governing its absorption after subcutaneous injection. Since normoglycaemia is the general aim nowadays, knowledge about the absorption process is important. In this review, the physiology and the pharmacological and clinical factors influencing the absorption rate are dealt with, resulting in recommendations for the injection procedure of insulin.