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The Estrogen Receptors: An Overview from Different Perspectives
1Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, 414 E. Clark St., Vermillion, SD, 57069, USA. Kathleen.Eyster@usd.edu.
Methods in Molecular Biology (Clifton, N.J.)
|November 21, 2015
Summary
Estrogen receptors (ERα, ERβ, GPER) are key to estrogen effects in many tissues, not just reproductive organs. This overview covers their historical, physiological, and structural aspects.
Area of Science:
- Endocrinology and Molecular Biology
Background:
- Estrogen receptors (ERα, ERβ, GPER) mediate estrogenic compound effects.
- These receptors are found in reproductive tissues, breast, bone, brain, liver, colon, skin, and salivary glands.
Purpose of the Study:
- To provide a comprehensive overview of estrogen receptors.
- To discuss estrogen action from multiple perspectives: historical, physiological, pharmacological, pathological, structural, and ligand-based.
Main Methods:
- Literature review and synthesis of existing knowledge on estrogen receptors.
Main Results:
- Estrogen receptors exhibit diverse tissue distribution beyond the reproductive tract.
- Estrogen action is influenced by historical, physiological, pharmacological, pathological, structural, and ligand factors.
Conclusions:
- Estrogen receptors play a critical role in various physiological processes across multiple organ systems.
- Understanding estrogen receptors requires a multifaceted approach considering their broad biological impact.
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