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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Arterial Stiffness, Kidney Function, and Chronic Kidney Disease Progression
Raymond R Townsend1, Hirofumi Tomiyama2
1Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa., USA.
Pulse (Basel, Switzerland)
|November 21, 2015
Summary
Arterial stiffness, a cardiovascular risk factor, is increasingly studied for its role in chronic kidney disease (CKD) progression. This review examines how arterial stiffness and pulse waveform measures predict kidney function decline over time.
Area of Science:
- Cardiovascular Physiology
- Nephrology
- Biomedical Engineering
Background:
- Arterial stiffness is a validated predictor of cardiovascular events.
- Its role in the progression of chronic kidney disease (CKD) is less understood.
- Noninvasive devices can measure arterial stiffness and estimate central pressure profiles.
Purpose of the Study:
- To review the relationship between arterial stiffness and kidney function decline in CKD.
- To explore the predictive utility of arterial stiffness measures in CKD progression.
- To discuss pulse wave velocity and pulse waveform contour analysis in relation to kidney function.
Main Methods:
- Review of longitudinal studies on arterial stiffness and kidney function.
- Analysis of pulse wave velocity as a measure of arterial stiffness.
- Examination of systolic and diastolic pulse waveform features.
- Inclusion of a table of cross-sectional studies.
Main Results:
- Arterial stiffness is an independent predictor of cardiovascular events.
- Limited data exists on the predictive utility of arterial stiffness in CKD progression.
- Longitudinal data is crucial for understanding the impact on kidney function decline.
Conclusions:
- Further research is needed to elucidate the role of arterial stiffness in CKD progression.
- Noninvasive measures of arterial stiffness may offer valuable insights into kidney health.
- Longitudinal studies are essential for establishing predictive relationships.
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