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Related Experiment Videos

Antimicrobic susceptibility testing. A personal perspective.

J C Sherris1

  • 1Department of Microbiology, University of Washington School of Medicine, Seattle.

Clinics in Laboratory Medicine
|June 1, 1989
PubMed
Summary
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Antimicrobic susceptibility testing has improved through standardization and organization. Ongoing challenges with opportunistic pathogens and resistance mechanisms necessitate continuous updates to testing methods.

Area of Science:

  • Microbiology
  • Clinical Diagnostics
  • Infectious Diseases

Background:

  • Antimicrobic susceptibility testing (AST) is crucial for guiding effective treatment of bacterial infections.
  • Historical development of AST has focused on improving accuracy and reproducibility.
  • Emerging challenges include the rise of opportunistic pathogens and novel resistance mechanisms.

Purpose of the Study:

  • To outline the historical development of antimicrobial susceptibility testing.
  • To highlight the impact of standardization and organizational advancements on AST performance.
  • To address current challenges and the need for updating AST protocols.

Main Methods:

  • Review of historical data and procedural developments in AST.
  • Analysis of factors contributing to improved AST performance.

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  • Consideration of technical aspects of automated procedures and specific assays.

    • Main Results:

    • Standardization and organizational efforts have significantly enhanced AST performance.
    • Opportunistic pathogens and new resistance mechanisms present ongoing challenges requiring updated methods.
    • Automated procedures and specific assays like Minimum Bactericidal Concentration (MBC) and serum bactericidal testing have technical considerations.

    Conclusions:

    • Continuous refinement of AST methods is essential to combat evolving antimicrobial resistance.
    • Standardization remains a cornerstone for reliable susceptibility testing.
    • Future efforts must address new pathogens and resistance mechanisms to maintain effective antimicrobial therapy.