Related Experiment Video
Updated: Mar 29, 2026

The use of SC1 Pluripotin to Support mESC Self-renewal in the Absence of LIF
Published on: November 18, 2009
Zscan10 is dispensable for maintenance of pluripotency in mouse embryonic stem cells
Mariko Yamane1, Setsuko Fujii1, Satoshi Ohtsuka1
1Laboratory for Pluripotent Stem Cell Studies, RIKEN Center for Developmental Biology (CDB), 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Abstract:
Zinc finger and SCAN domain-containing 10 (Zscan10, also known as Zfp206) encodes a transcription factor that has been reported to be involved in the maintenance of pluripotency in mouse embryonic stem (ES) cells. Here we generated inducible knockout ES cells for Zscan10 using the Cre-loxP system and analyzed its function. We succeeded in establishing Zscan10-null ES cells and confirmed their pluripotency by the generation of chimeric embryos. Our results clearly indicate that Zscan10 is dispensable for the ability of self-renewal and differentiation in ES cells.

