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Study of Subchronic Toxicity of Relatox on Sexually Immature Animals
A A Churin1, T I Fomina2, L A Ermolaeva2
1E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. toxicology_lab@mail.ru.
Bulletin of Experimental Biology and Medicine
|November 24, 2015
Abstract:
Intramuscular injections of Relatox in therapeutic and toxic doses to young outbred laboratory rats for 14 days caused no changes in the peripheral blood and bone marrow parameters, serum biochemical parameters, and morphology of the major viscera. In the toxic dose, the drug caused local irritation (inflammation, atrophy, and sclerosis in muscle tissue). Regeneration processes started in muscle tissue 7 days after Relatox withdrawal.