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High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
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Self-Sterilizing, Self-Cleaning Mixed Polymeric Multifunctional Antimicrobial Surfaces.

Harry C Pappas1,2, Samantha Phan3, Suhyun Yoon4

  • 1Department of Nanoscience and Microsystems Engineering, University of New Mexico , Albuquerque, New Mexico 87131-1341, United States.

ACS Applied Materials & Interfaces
|November 25, 2015
PubMed
Summary
This summary is machine-generated.

This study presents a novel surface modification strategy using antimicrobial poly(p-phenylene ethynylene) and switchable poly(N-isopropylacrylamide) polymers to prevent hospital-acquired infections by controlling microbial adhesion and killing bacteria.

Keywords:
PNIPAAmbacteriaconjugated polyelectrolytekillrelease

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Area of Science:

  • Materials Science
  • Biotechnology
  • Surface Chemistry

Background:

  • Hospital-acquired infections are a significant concern, often stemming from bacterial adhesion and biofilm formation on surfaces.
  • Current strategies focus on preventing microbial attachment and inactivating microbes, but a combined approach is needed.

Purpose of the Study:

  • To develop a surface modification strategy that combines switchable microbial capture and inactivation.
  • To create a multifunctional surface capable of preventing bacterial adhesion and eliminating pathogens.

Main Methods:

  • Fabrication of active surfaces using layer-by-layer assembly of biocidal poly(p-phenylene ethynylene) and switchable poly(N-isopropylacrylamide) polymers.
  • Utilizing surface-attached polymerization initiators to grow poly(N-isopropylacrylamide) through the poly(p-phenylene ethynylene) layer.
  • Characterization of the physical and functional properties of the resulting complex films.

Main Results:

  • The developed surfaces demonstrate efficient inactivation of a broad spectrum of microbes, including Gram-negative and Gram-positive bacteria.
  • The poly(N-isopropylacrylamide) component enables switchable binding and release of microbes based on temperature-induced surface property changes.
  • The combined system effectively kills surface-bound microbes and subsequently induces their release.

Conclusions:

  • This novel surface modification strategy offers a promising approach for preventing hospital-acquired infections.
  • The ability to control both microbial adhesion and inactivation provides a powerful tool for infection control.
  • The developed materials show potential for applications in medical devices and surfaces requiring antimicrobial properties.