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Updated: Mar 29, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Atrial Fibrillation During Cardiac Resynchronization Therapy

Mariëlle Kloosterman1, Alexander H Maass1, Michiel Rienstra1

  • 1Department of Cardiology, Thoraxcenter, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.

Cardiac Electrophysiology Clinics
|November 25, 2015
PubMed

Insights

Cardiac resynchronization therapy (CRT) shows reduced efficacy in patients with atrial fibrillation (AF). Effective biventricular pacing is crucial for managing AF patients undergoing CRT.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Landmark trials for cardiac resynchronization therapy (CRT) primarily included patients in sinus rhythm.
  • Atrial fibrillation (AF) is highly prevalent (20-40%) in patients receiving CRT, yet its impact on CRT efficacy is understudied.

Purpose of the Study:

  • To review the detrimental effects of AF on CRT response.
  • To discuss management strategies for patients with AF undergoing CRT.

Main Methods:

  • Literature review focusing on studies investigating CRT in patients with AF.
  • Analysis of factors influencing CRT response in the presence of AF.

Main Results:

  • AF significantly impacts the effectiveness of CRT.
  • Uncertainty exists regarding the AF burden thresholds that diminish CRT response.

Conclusions:

  • Successful biventricular pacing is essential for optimizing CRT outcomes in AF patients.
  • Further research is needed to define AF burden thresholds and refine management strategies.

Keywords:
Atrioventricular junction ablationBiventricular pacingHeart failureImplantation

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