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Fertility Preservation in Patients with Severe Ovarian Dysfunction
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[Ovarian failure: New treatments in perspective?]

C Ravel1, N Kazdar2, J Leveque3

  • 1Laboratoire de biologie de la reproduction, CHU de Rennes, 2, rue Henri-Le-Guillou, 35033 Rennes, France; Faculté de médecine, université Rennes 1, 35043 Rennes, France; Inserm, IRSET U1085, 263, avenue du Général-Leclerc, 35042 Rennes cedex, France.

Gynecologie, Obstetrique & Fertilite
|November 25, 2015
PubMed

Insights

Premature ovarian failure impacts oocyte quality, leading to chromosomal and mitochondrial defects. Cellular therapies offer promising treatments for ovarian failure, addressing its underlying mechanisms.

Area of Science:

  • Reproductive Biology
  • Cellular Therapy
  • Ovarian Physiology

Background:

  • Premature loss of ovarian function has significant physical and psychological effects.
  • Oocyte quality is compromised by declining ovarian reserve and advanced maternal age.
  • These factors contribute to chromosomal defects, altered gene expression, and mitochondrial dysfunction.

Purpose of the Study:

  • To explore the mechanisms underlying premature ovarian function loss.
  • To investigate the impact of ovarian reserve decline and maternal age on oocyte quality.
  • To highlight potential cellular therapies for ovarian failure.

Main Methods:

  • Review of existing literature on ovarian function, oocyte quality, and aging.
  • Analysis of factors affecting oocyte defects (chromosomal, gene expression, mitochondrial).
  • Evaluation of current and emerging cellular therapeutic approaches.

Main Results:

  • Ovarian reserve decline and advanced maternal age are key contributors to oocyte defects.
  • Specific defects include chromosomal abnormalities, altered gene expression, and mitochondrial pattern changes.
  • Cellular therapies show potential in restoring ovarian function.

Conclusions:

  • Understanding the mechanisms of premature ovarian failure is crucial.
  • Oocyte quality is significantly impacted by age and reserve.
  • Ovarian follicle activation and ovarian stem cell isolation are promising therapeutic avenues.
Keywords:
Activation folliculaireCellules souchesFertilityFertilitéFollicle activationGeneticsGénétiqueInsuffisance ovarienneOvarian failureStem cells

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