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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
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Innate lymphoid type 2 cells in chronic rhinosinusitis
Sarah Vreugde1, Peter-John Wormald
1Department of Surgery - Otorhinolaryngology Head and Neck Surgery, The Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia.
Current Opinion in Allergy and Clinical Immunology
|November 25, 2015
Summary
Innate lymphoid type 2 cells (ILC2) are crucial for type 2 immunity and tissue repair. Their role in chronic rhinosinusitis and other inflammatory diseases is increasingly recognized.
Area of Science:
- Immunology
- Cell Biology
Background:
- Innate lymphoid type 2 cells (ILC2) are key players in type 2 immunity, producing critical cytokines.
- ILC2s are involved in immune responses at barrier surfaces and in tissue homeostasis.
Purpose of the Study:
- To review recent findings on the role of ILC2 in integrating innate and adaptive immunity.
- To explore the potential involvement of ILC2 in chronic rhinosinusitis.
Main Methods:
- Literature review of recent research on ILC2 function.
- Analysis of ILC2 involvement in various inflammatory and homeostatic processes.
Main Results:
- ILC2s exhibit complex crosstalk with various immune cells.
- ILC2s are vital for type 2 immune responses, tissue repair, and homeostasis.
- ILC2-derived IL-13 is particularly important in airway diseases like asthma.
Conclusions:
- ILC2 research has significantly advanced understanding of type 2 immune responses.
- ILC2s are implicated in diverse conditions including asthma, chronic rhinosinusitis, and atopic dermatitis.
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