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New clerodane diterpenoids from Croton crassifolius
Maosong Qiu1, Di Cao1, Youheng Gao1
1School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Abstract:
Two new clerodane diterpenoids (1-2), one new clerodane diterpenoid alkaloid (3), as well as thirteen known compounds were isolated from Croton crassifolius. The structures of new compounds were established by a combination of spectroscopic methods, including HRMS, (1)H NMR, (13)C NMR, (1)H (1)H COSY, HSQC, HMBC, NOESY and X-ray crystallographic analysis. Compound 3 is firstly reported as the clerodane-type diterpenoid alkaloid in natural products. All of the compounds were evaluated for in vitro cytotoxic activities against CT26.WT cell using the MTT method.
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