Related Experiment Video
Updated: Mar 29, 2026
14:27
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
16.5K
Active Surveillance: Pathologic and Clinical Variables Associated with Outcome
1Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, D1230, Boston, MA 02115, USA.
Surgical Pathology Clinics
|November 28, 2015
Summary
Active surveillance is a key option for low-risk prostate cancer, preserving quality of life. New biomarkers and imaging can improve risk assessment for selecting ideal candidates for this approach.
Area of Science:
- Oncology
- Urology
Background:
- Active surveillance is increasingly used for low-risk prostate cancer.
- Curative treatments carry significant morbidity, impacting quality of life.
- Active surveillance aims to maintain quality of life by avoiding treatment for indolent disease.
Purpose of the Study:
- To highlight the need for improved risk stratification metrics in active surveillance for prostate cancer.
- To discuss the potential of emerging biomarkers and imaging technologies in identifying suitable candidates.
Main Methods:
- Review of current practices in active surveillance for prostate cancer.
- Discussion of existing pathologic and clinical variables for risk assessment.
- Exploration of novel biomarker and imaging technologies.
Main Results:
- Current methods using pathologic and clinical data aid in determining active surveillance suitability.
- Emerging biomarkers and advanced imaging show promise for more precise risk assessment.
- Improved metrics are crucial for expanding the safe application of active surveillance.
Conclusions:
- Active surveillance is a valuable management strategy for low-risk prostate cancer.
- Enhanced risk assessment tools are essential for optimizing candidate selection.
- Future research should focus on validating new biomarkers and imaging for active surveillance.
Related Concept Videos
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
533
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
533
01:26Principles of Disease Surveillance
788
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
788
01:21Cancer Survival Analysis
830
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
830
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
513
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
513
01:23Investigation of Disease Outbreaks
44
Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
44
01:16Clinical Trials
11.1K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
11.1K