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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Mar 29, 2026

Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

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Published on: November 13, 2017

Cell Microarrays for Biomedical Applications.

Mario Rothbauer¹, Verena Charwat², Peter Ertl³

¹BioSensor Technologies, AIT Austrian Institute of Technology GmbH, Muthgasse 11, 1190, Vienna, Austria.

Methods in Molecular Biology (Clifton, N.J.)

|November 29, 2015

Summary

This summary is machine-generated.

This chapter reviews live cell microarrays for high-throughput biological assays, covering fabrication, applications in biomaterials, stem cell biology, and neuroscience, and the role of microfluidics.

Keywords:

Cell microarray Integrated microdevices Microfluidic Organoids Single cell Spheroids

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Last Updated: Mar 29, 2026

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Area of Science:

Biotechnology
Cell Biology
Materials Science

Background:

Live cell microarrays enable high-throughput biological assays.
Advancements in material science and cell patterning are crucial for microarray fabrication.
Microfluidic technologies are increasingly important for live-cell assays.

Purpose of the Study:

To review the state of the art in live cell microarray technology.
To discuss fabrication methods including material science and cell patterning.
To highlight applications and the role of microfluidics in live cell microarrays.

Main Methods:

Review of current literature on live cell microarrays.
Discussion of fabrication techniques for novel microarrays.
Analysis of applications in biomaterials, stem cell biology, and neuroscience.
Emphasis on microfluidic integration for on-chip assays.

Main Results:

Live cell microarrays offer a powerful platform for high-throughput screening.
Novel fabrication methods enhance microarray capabilities.
Applications span diverse research areas, demonstrating broad utility.
Microfluidics enables sophisticated single-cell, multi-cell, and 3D tissue construct assays.

Conclusions:

Live cell microarrays are a key technology for advancing biological research.
Integration with microfluidics significantly enhances assay capabilities.
The technology holds great promise for future discoveries in various scientific fields.