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Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
Osteoarthritis prevalence and modifiable factors: a population study
Ronald Plotnikoff1, Nandini Karunamuni2, Ellina Lytvyak3
1Priority Research Centre for Physical Activity and Nutrition, University of Newcastle, Callaghan, NSW, 2308, Australia. ronald.plotnikoff@newcastle.edu.au.
Osteoarthritis (OA) affects 14.8% of adults, with higher prevalence in females and older age groups. Obesity significantly increases knee and hip OA risk, while certain physical activities and vitamin C intake may be protective.
Area of Science:
- Epidemiology
- Rheumatology
- Public Health
Background:
- Osteoarthritis (OA) is a prevalent joint disease affecting knee and hip joints.
- Understanding OA prevalence across demographics and modifiable risk factors is crucial for public health interventions.
Purpose of the Study:
- To determine the prevalence of self-reported knee and hip osteoarthritis (OA) stratified by age and sex.
- To investigate the association between modifiable factors and the prevalence of knee and hip OA.
Main Methods:
- A population-based sample of 4733 adults (≥18 years) from Alberta, Canada, was surveyed.
- Data on self-reported OA, demographics, and modifiable factors were collected via telephone interviews and community clinics.
- Binary logistic regression was used to analyze associations between modifiable factors and OA prevalence.
Main Results:
- Overall OA prevalence was 14.8% (knee OA: 10.5%, hip OA: 8.5%).
- Obesity (BMI >30 kg/m²) significantly increased the odds of both knee (OR: 4.37) and hip OA (OR: 2.52).
- Certain occupational activities (standing/walking, light loads, stair climbing) and higher vitamin C intake were associated with lower hip OA prevalence.
Conclusions:
- Knee and hip OA prevalence in this Canadian population is comparable to other studies.
- Females exhibit higher knee OA prevalence and report more mobility limitations and pain.
- Targeting modifiable factors like obesity and promoting protective occupational activities and vitamin C intake are important for OA management.
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