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[Anaplastic large-cell lymphoma CD30(+) ALK(+)].

L Kollarikova1, M Heizerova2, M Simaljakova2

  • 1Klinik für Dermatologie und Venerologie der Medizinischen Fakultät, Comenius Universität, Mickiewiczova 13, 813 69, Bratislava, Slowakei. luciaslov@yahoo.com.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|December 2, 2015
PubMed
Summary

A rare form of anaplastic large-cell lymphoma (ALCL) presented with skin involvement in a 32-year-old man. Prompt diagnosis via immunophenotyping and treatment with chemotherapy and radiotherapy led to complete remission.

Keywords:
ChemotherapyHistologyImmunophenotypingPrimary systemic lymphomaRadiotherapy

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Area of Science:

  • Hematology
  • Oncology
  • Dermatology

Background:

  • Anaplastic large-cell lymphoma (ALCL) is a distinct type of non-Hodgkin lymphoma.
  • Primary systemic ALCL can present with extranodal involvement, including skin.

Observation:

  • A 32-year-old male presented with skin manifestations suggestive of a hematologic malignancy.
  • Initial histological examinations were inconclusive, delaying diagnosis.
  • A third biopsy with immunophenotyping was crucial for identifying CD30(+) ALK(+) ALCL.

Findings:

  • The patient was diagnosed with primary systemic anaplastic large-cell lymphoma.
  • Treatment involved a combination of chemotherapy and adjuvant radiotherapy.
  • Complete remission was achieved post-treatment.

Implications:

  • This case highlights the importance of thorough diagnostic workup, including immunophenotyping, for challenging ALCL presentations.
  • It underscores the efficacy of combined modality treatment in achieving long-term remission for ALCL.
  • Early and accurate diagnosis of cutaneous ALCL is critical for effective management and improved patient outcomes.