[Kinetics of insulin disappearance from rat plasma]

Kinetics of insulin elimination from blood plasma was studied using intact rats administered intravenously with 125I-insulin. Kinetic parameters of the hormone removal from blood plasma corresponded to two-phase pharmacokinetic model, where insulin disappeared from central and peripheric compartments. The kinetic parameters studied might be used in evaluation of true volumes of blood plasma in circulation and in intracellular space as well as in studies of vessels permeability for insulin and the state of the pool of physiologically active receptors of insulin in vivo.