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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
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Androgens, body fat Distribution and Adipogenesis
Mouna Zerradi1,2, Julie Dereumetz1,2, Marie-Michèle Boulet1,2
1Endocrinology and Nephrology, CHU de Quebec Research Center, 2705 Laurier Blvd. R-4779, Quebec City, PQ, Canada, G1V 4G2.
Current Obesity Reports
|December 3, 2015
Summary
Androgens regulate fat cell functions, influencing body fat distribution. Research shows testosterone and dihydrotestosterone can inhibit fat cell differentiation, impacting lipid storage and metabolism.
Area of Science:
- Endocrinology
- Metabolic Research
- Adipose Tissue Biology
Background:
- Androgens play a crucial role in regulating adipocyte functions, including adipogenesis, lipid storage, and lipolysis.
- These hormones may influence body fat distribution through depot-specific effects on fat cells.
Purpose of the Study:
- To investigate the role of androgens in modulating adipocyte functions and body fat distribution.
- To explore the depot-specific and sex-specific effects of androgens on lipid metabolism.
Main Methods:
- Review of existing models and primary cultures of human adipocytes from men and women.
- Analysis of androgen effects on preadipocyte differentiation and markers of lipid metabolism (e.g., LPL activity, fatty acid uptake, lipolysis).
Main Results:
- Testosterone and dihydrotestosterone were shown to inhibit preadipocyte differentiation into lipid-storing adipocytes.
- Androgen effects on lipid metabolism markers and depot/sex specificity were observed in some models.
- Local transformation and inactivation of androgens in adipose tissue can modulate hormone availability.
Conclusions:
- Androgens significantly impact adipocyte function and lipid metabolism.
- Depot-specific and sex-specific effects, along with local androgen metabolism and interactions with glucocorticoids, likely contribute to human body fat distribution patterns.
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