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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
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Related Experiment Video

Updated: Mar 29, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
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Targeting Tumors with Small Molecule Peptides.

Andrew G Cheetham, Daniel Keith, Pengcheng Zhang

  • 1Department of Chemical and Biomolecular Engineering, and Institute for NanoBioTechnology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, United States. hcui6@jhu.edu.

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Peptide ligands offer a promising strategy for targeted cancer therapy and diagnostics. This review explores their use in delivering chemotherapy and aiding in cancer detection.

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Area of Science:

  • Oncology
  • Drug Delivery
  • Molecular Imaging

Background:

  • Chemotherapy faces challenges with poor tumor selectivity, affecting healthy tissues.
  • Targeting elements are crucial for preferential drug delivery to tumor sites.

Purpose of the Study:

  • To review recent advancements in peptide-based targeting ligands for cancer therapy.
  • To discuss the diagnostic applications of peptide ligands in cancer detection and characterization.

Main Methods:

  • Highlighting examples of peptide ligands used to deliver chemotherapeutic payloads.
  • Examining the incorporation of peptide ligands into cancer imaging agents.

Main Results:

  • Peptide ligands demonstrate potential for selective delivery to tumor vasculature, lymphatics, and cell surfaces.
  • Peptide-based agents show promise for cancer diagnostics and characterization.

Conclusions:

  • Peptide targeting ligands offer a versatile approach for improving cancer treatment efficacy and diagnostic capabilities.
  • Further development is needed to fully realize the potential of peptide-based strategies in oncology.