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Cushing's syndrome.

D E Schteingart1

  • 1Division of Endocrinology and Metabolism, University of Michigan Medical School, Ann Arbor.

Endocrinology and Metabolism Clinics of North America
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

Cushing

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Area of Science:

  • Endocrinology
  • Internal Medicine

Background:

  • Cushing's syndrome involves excess cortisol production.
  • Pathophysiology includes pituitary or ectopic ACTH-dependent and ACTH-independent causes.

Purpose of the Study:

  • Review clinical characteristics and pathophysiology of Cushing's syndrome.
  • Discuss diagnostic and therapeutic strategies.

Main Methods:

  • Biochemical testing and anatomic localization for diagnosis.
  • Transsphenoidal pituitary microsurgery for treatment.
  • Pharmacologic agents targeting different pathways.

Main Results:

  • Transsphenoidal surgery achieves 80-90% remission for pituitary ACTH-dependent Cushing's.
  • Medical therapies offer temporary solutions or adjuvant roles.
  • Mitotane shows efficacy in adrenal carcinoma but has toxicity concerns.

Conclusions:

  • Transsphenoidal microsurgery is the preferred treatment for pituitary ACTH-dependent Cushing's syndrome.
  • Medical management is crucial for specific situations and future drug development is promising.