Related Experiment Video

Updated: Mar 29, 2026

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease
04:11

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease

Published on: April 28, 2023

2.8K

Antisecretory therapy with no improvement in functional level in Ménière's disease

Charlotte J Ingvardsen1, Mads Klokker1

  • 1a Department of Otorhinolaryngology, Head & Neck Surgery and Audiology , Rigshospitalet, University of Copenhagen , Denmark.

Acta Oto-Laryngologica
|December 5, 2015
PubMed

Insights

Antisecretory factor-inducing specially processed cereals (SPC) did not significantly improve Ménière

Area of Science:

  • Otolaryngology
  • Nutrition Science
  • Clinical Research

Background:

  • Ménière's disease (MD) is a complex inner ear disorder.
  • Current treatments for MD have limitations.
  • AF-inducing SPC offers a novel therapeutic approach.

Purpose of the Study:

  • To evaluate the efficacy of AF-inducing SPC in managing Ménière's disease.
  • To assess the impact of SPC on functional levels and attack frequency in MD patients.

Main Methods:

  • Randomized, double-blinded, placebo-controlled cross-over study design.
  • Two-month intervention periods with SPC and control cereal, separated by a two-month washout.
  • Severity assessed using the AOO-HNS functional scale; attack frequency was recorded.

Main Results:

  • No significant improvement in functional level or attack frequency observed with SPC compared to placebo.
  • Slight improvements in functional level were noted in both SPC and placebo groups.
  • No worsening of functional level occurred with SPC, unlike with placebo.

Conclusions:

  • AF-inducing SPC did not demonstrate significant therapeutic benefits for Ménière's disease.
  • Further research may be needed to explore alternative applications or formulations of SPC.
Keywords:
Antisecretory factorMénière’s diseasespecially processed cereals

More Related Videos

Surgical Treatment of an Endolymphatic Sac Tumor04:34

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

1.8K
A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

14.2K

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
571
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
320
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion01:22

Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion

The kidneys maintain homeostasis through filtration, reabsorption, and secretion. Tubular reabsorption and secretion are crucial in forming urine and regulating electrolytes, water balance, and waste elimination.Tubular Reabsorption and Secretion ProcessesTubular reabsorption is the process that reclaims essential substances such as electrolytes, glucose, amino acids, and water from the glomerular filtrate back into the bloodstream. This is achieved through passive and active transport...
2.0K
Disorder of Water Balance01:29

Disorder of Water Balance

Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
2.8K