Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondria01:37

Mitochondria

21.3K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.3K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

10.0K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
10.0K
Epigenetic Regulation01:37

Epigenetic Regulation

4.2K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.2K
Epigenetic Regulation01:46

Epigenetic Regulation

34.3K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.3K
Replication in Eukaryotes01:29

Replication in Eukaryotes

18.9K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
18.9K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Transcription Factor NRF2 in Endothelial Functions].

Molekuliarnaia biologiia·2023
Same author

Mitochondrion-targeted antioxidant SkQ1 prevents rapid animal death caused by highly diverse shocks.

Scientific reports·2023
Same author

Effect of Antioxidants on the Production of MCP-1 Chemokine by EA.hy926 Cells in Response to IL-6.

Moscow University biological sciences bulletin·2022
Same author

COVID-19 and Oxidative Stress.

Biochemistry. Biokhimiia·2021
Same author

Transcription Factor Nrf2 as a Potential Therapeutic Target for Prevention of Cytokine Storm in COVID-19 Patients.

Biochemistry. Biokhimiia·2020
Same author

A Combination of Kidney Ischemia and Injection of Isolated Mitochondria Leads to Activation of Inflammation and Increase in Mortality Rate in Rats.

Bulletin of experimental biology and medicine·2020

Related Experiment Video

Updated: Mar 29, 2026

Methodology for Accurate Detection of Mitochondrial DNA Methylation
12:11

Methodology for Accurate Detection of Mitochondrial DNA Methylation

Published on: May 20, 2018

14.0K

DNA Methylation, Mitochondria, and Programmed Aging.

L A Zinovkina1, R A Zinovkin

  • 1Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, 119991, Russia.

Biochemistry. Biokhimiia
|December 8, 2015
PubMed
Summary
This summary is machine-generated.

DNA methylation regulates gene expression and biological age. This review explores nuclear and mitochondrial DNA methylation in mammals, linking them to programmed aging and oxidative stress.

More Related Videos

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

10.4K
Detection of Modified Forms of Cytosine Using Sensitive Immunohistochemistry
07:13

Detection of Modified Forms of Cytosine Using Sensitive Immunohistochemistry

Published on: August 16, 2016

7.9K

Related Experiment Videos

Last Updated: Mar 29, 2026

Methodology for Accurate Detection of Mitochondrial DNA Methylation
12:11

Methodology for Accurate Detection of Mitochondrial DNA Methylation

Published on: May 20, 2018

14.0K
Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

10.4K
Detection of Modified Forms of Cytosine Using Sensitive Immunohistochemistry
07:13

Detection of Modified Forms of Cytosine Using Sensitive Immunohistochemistry

Published on: August 16, 2016

7.9K

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Gerontology

Background:

  • DNA methylation is crucial for regulating nuclear gene expression and determining biological age.
  • The role of mitochondrial DNA (mtDNA) methylation in cellular processes remains largely unexplored.
  • Emerging research connects mtDNA methylation to aging and oxidative stress.

Purpose of the Study:

  • To summarize current knowledge on nuclear and mitochondrial DNA methylation in mammals.
  • To highlight the potential links between DNA methylation and programmed aging.
  • To underscore the need for further research into mtDNA methylation's functional significance.

Main Methods:

  • Literature review of studies on DNA methylation in mammals.
  • Analysis of research linking epigenetic modifications to aging processes.
  • Synthesis of findings on nuclear and mitochondrial DNA methylation patterns.

Main Results:

  • Genomic DNA methylation sites accurately reflect biological age.
  • Mitochondrial DNA methylation is increasingly associated with aging and oxidative stress.
  • Both nuclear and mitochondrial DNA methylation processes are implicated in mammalian aging.

Conclusions:

  • Mitochondrial DNA methylation warrants further investigation for its functional role in aging.
  • Understanding DNA methylation in both nuclear and mitochondrial genomes is key to unraveling aging mechanisms.
  • Epigenetic regulation, including DNA methylation, plays a significant role in programmed aging.