CLINDAMYCIN: EFFECTS ON PLASMA LIPID PROFILE AND PEROXIDATION PARAMETERS IN RABBIT BLOOD PLASMA

Alteration of plasma lipid profile and induction of lipid peroxidation may take place due to drug effect, which may be correlated with adverse drug reactions and drug-induced toxicity. Considering this fact, the present in vivo study was carried out to evaluate the effect of clindamycin on plasma lipid profile and peroxidation parameters alone and in combination with ascorbic acid, a promising antioxidant. After administering drug and antioxidant alone and in combination in rabbit, it was found that clindamycin had mild lipid peroxidation induction and profile alteration capacity, which can be arrested on co-administration of ascorbic acid.