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A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Assessment of Nephroprotective Potential of Histochrome during Induced Arterial Hypertension
I G Agafonova1, R N Bogdanovich2, N G Kolosova3,4
1G. B. Elyakov Pacific Ocean Institute of Bioorganic Chemistry, Far-East Division of Russian Academy of Sciences, Novosibirsk, Russia. agafonova@piboc.dvo.ru.
Abstract:
Magnetic resonance tomography was employed to verify endothelial dysfunction of renal arteries in Wistar and OXYS rats under conditions of induced arterial hypertension. Angiography revealed changes in the size and form of renal arteries of hypertensive animals. In hypertensive rats, histochrome exerted a benevolent therapeutic effect in renal arteries: it decreased BP, diminished thrombus formation in fi ne capillaries and arterioles, demonstrated the anticoagulant properties, partially improved endothelial dysfunction of small renal arteries, and up-regulated the glomerular filtration.
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