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Drug delivery by phonophoresis
1Sandoz Research Institute, Sandoz Pharmaceuticals Corporation, Lincoln, Nebraska 68501.
Pharmaceutical Research
|May 1, 1989
Summary
Phonophoresis uses ultrasound to deliver drugs through the skin. This review covers drug delivery systems, affecting parameters, and available devices for this emerging technique.
Area of Science:
- Biomedical Engineering
- Pharmacology
- Dermatology
Background:
- Phonophoresis facilitates transdermal drug molecule migration via ultrasound.
- It enables drug introduction into the body through a contact agent.
- Current phonophoretic drug delivery systems are under development.
Purpose of the Study:
- To review the principles of phonophoresis for drug delivery.
- To discuss factors influencing drug permeation via ultrasound.
- To survey existing and developing phonophoretic devices.
Main Methods:
- Literature review of phonophoresis research.
- Analysis of parameters affecting ultrasound-mediated drug transport.
- Examination of current device designs for phonophoresis.
Main Results:
- Phonophoresis is a viable method for transdermal drug delivery.
- Ultrasound intensity, frequency, and drug properties influence delivery efficiency.
- Various device prototypes are being explored for clinical application.
Conclusions:
- Phonophoresis shows promise for novel drug delivery applications.
- Further research is needed to optimize phonophoretic systems.
- Standardization of devices and parameters will enhance clinical utility.