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Updated: Mar 29, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
SEVERE PANUVEITIS, RETINAL VASCULITIS, AND OPTIC DISK GRANULOMA SECONDARY TO SARCOIDOSIS
Michael Patterson1, Chris S Bergstrom, W Lloyd Clark
1*Department of Ophthalmology, University of South Carolina, Columbia, South Carolina; †Department of Ophthalmology, Emory Eye Center, Atlanta, Georgia; and ‡Palmetto Retina Center, West Columbia, South Carolina.
Purpose:
To report a case of panuveitis, retinal vasculitis, and optic disk granuloma due to sarcoidosis.
Methods:
Case report and literature review.
Results:
A 26-year-old previously healthy African American male presented with four months of gradual progressive visual decline in the right eye. Clinical examination revealed severe panuveitis, retinal vasculitis, and large optic nerve mass lesion. Diffuse supraclavicular lymphadenopathy was also present. Histopathologic examination of the lymph node biopsy revealed granulomatous inflammation with some areas of caseous necrosis consistent with sarcoidosis.
Conclusion:
Sarcoidosis is a common cause of uveitis and retinal vasculitis. In rare cases, an optic disk granuloma may occur and can be treated with immunosuppressive therapy.
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