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Ankylosing spondylitis without HLA B27.

J M Van der Linden, K De Ceulaer, L K Van Romunde

    The Journal of Rheumatology. Supplement
    |January 1, 1977
    PubMed
    Summary
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    Human leukocyte antigen B27 (HLA B27) is linked to ankylosing spondylitis. However, this study found that other factors also contribute to the development of this chronic inflammatory disease.

    Area of Science:

    • Rheumatology
    • Immunogenetics

    Background:

    • Ankylosing spondylitis is a chronic inflammatory disease primarily affecting the spine.
    • The human leukocyte antigen B27 (HLA B27) is strongly associated with ankylosing spondylitis, but its exact role remains incompletely understood.

    Purpose of the Study:

    • To investigate the role of HLA B27 in the development of ankylosing spondylitis.
    • To identify potential non-HLA B27 factors contributing to the disease.

    Main Methods:

    • Retrospective analysis of 187 patients with a diagnosis of definite ankylosing spondylitis.
    • Comparison of clinical signs and symptoms between HLA B27 positive and negative patient cohorts.

    Main Results:

    • Out of 187 patients, 17 (9.1%) lacked the HLA B27 antigen.

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  • These 17 HLA B27 negative patients exhibited clinical manifestations identical to the 170 HLA B27 positive patients.

    • Conclusions:

    • The findings confirm that HLA B27 is not the sole factor in the pathogenesis of ankylosing spondylitis.
    • Additional genetic or environmental factors likely play a significant role in disease development, even in the absence of HLA B27.