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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Updated: Mar 28, 2026

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
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Pharmacologic Therapies for Pediatric Concussions.

Mark E Halstead

    Sports Health
    |December 15, 2015
    PubMed
    Summary

    Current evidence does not support medication use for pediatric concussions. Further research is needed to explore potential benefits of pharmacotherapy for young athletes experiencing concussion symptoms.

    Area of Science:

    • Pediatric neurology
    • Sports medicine
    • Clinical pharmacology

    Background:

    • Pediatric concussions are prevalent, with guidelines emphasizing accurate diagnosis and management.
    • While medications may play a role, there is no established consensus on pharmacologic therapy for concussions.

    Purpose of the Study:

    • To review the current evidence regarding pharmacologic interventions for pediatric sport-related concussions.
    • To identify any established or potential medication benefits for managing concussion in young athletes.

    Main Methods:

    • A nonsystematic review of clinical literature was conducted.
    • The study design involved a clinical review of existing evidence.
    • The level of evidence was determined to be Level 4.

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    Last Updated: Mar 28, 2026

    A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
    07:01

    A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

    Published on: February 7, 2025

    957
    An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System
    07:02

    An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

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    Main Results:

    • Limited evidence suggests hypertonic saline may help posttraumatic headaches in emergency settings.
    • There is a lack of evidence supporting the use of other medications for managing pediatric sport-related concussions.

    Conclusions:

    • Further research is essential to ascertain the efficacy of pharmacotherapy in managing concussions among pediatric athletes.
    • The current evidence base is insufficient to recommend specific medications for this population.