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Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron
Published on: August 12, 2019
Expedient Iron-Catalyzed C-H Allylation/Alkylation by Triazole Assistance with Ample Scope
Gianpiero Cera1, Tobias Haven1, Lutz Ackermann2
1Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077, Göttingen, Germany.
Abstract:
Triazole assistance set the stage for a unified strategy for the iron-catalyzed C-H allylation of arenes, heteroarenes, and alkenes with ample scope. The versatile catalyst also proved competent for site-selective methylation, benzylation, and alkylation with challenging primary and secondary halides. Triazole-assisted C-H activation proceeded chemo-, site-, and diastereo-selectively, and the modular TAM directing group was readily removed in a traceless fashion under exceedingly mild reaction conditions.
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