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Updated: Mar 28, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL AND PHYTOTOXIC SCREENING OF 1-AROYL-3,5-DIARYLPYRAZOLINE DERIVATIVES
Abstract:
Pyrazolines are biologically and pharmaceutically very active scaffolds. Derivatives of. (3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)(phenyl)methanone were synthesized by the cyclization of chalcones (1a-c) with substituted benzyl hydrazides (2a-e) using a few drops of piperidine as catalyst. Structures of all the synthesized compounds were confirmed by FTIR, 1H NMR, 13C NMR and mass spectrometric analysis. All the pyrazolines were subjected to antimicrobial and phytotoxic assays. Compound 3a and 3c showed maximum antimicrobial activities while all the synthesized compounds were active acc. to their phytotoxic assays.
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