Related Experiment Video
Updated: Mar 28, 2026

Capturing Chromosome Conformation Across Length Scales
Published on: January 20, 2023
ChromContact: A web tool for analyzing spatial contact of chromosomes from Hi-C data
Tetsuya Sato1,2, Mikita Suyama3,4
1Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan. sato@bioreg.kyushu-u.ac.jp.
Background:
Hi-C analysis has revealed the three-dimensional architecture of chromosomes in the nucleus. Although Hi-C data contains valuable information on long-range interactions of chromosomes, the data is not yet widely utilized by molecular biologists because of the quantity of data.
Results:
We developed a web tool, ChromContact, to utilize the information obtained by Hi-C. The web tool is designed to be simple and easy to use. By specifying a locus of interest, ChromContact calculates contact profiles and generates links to the UCSC Genome Browser, enabling users to visually examine the contact information with various annotations.
Conclusion:
ChromContact provides wide-range of molecular biologists with a user-friendly means to access high-resolution Hi-C data. One of the possible applications of ChromContact is investigating novel long-range promoter-enhancer interactions. This facilitates the functional interpretation of statistically significant markers identified by GWAS or ChIP-seq peaks that are located far from any annotated genes. ChromContact is freely accessible at http://bioinfo.sls.kyushu-u.ac.jp/chromcontact/ .
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