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Updated: Mar 28, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Lung Cancer Statistics.

Lindsey A Torre¹, Rebecca L Siegel¹, Ahmedin Jemal²

¹Surveillance and Health Services Research, Intramural Research Department, American Cancer Society, 250 Williams Street, 30303, Atlanta, Georgia, USA.

Advances in Experimental Medicine and Biology

|December 16, 2015

Summary

This summary is machine-generated.

Lung cancer remains a leading cause of cancer death globally and in the US. Incidence and mortality patterns show significant variations by demographics and geography, influenced by historical smoking trends.

Keywords:

Age Age-standardized rate (ASR)Cancer burden Cancer incidence Cancer mortality Cancer statistics Five-year relative survival Global Global patterns International Lung cancer Race/ethnicity Socioeconomic status (SES) geographic variation Trends United States

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Last Updated: Mar 28, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Area of Science:

Oncology
Epidemiology
Public Health

Background:

Lung cancer is the primary cause of cancer mortality in the United States and a leading cause worldwide.
Significant disparities in lung cancer rates exist across sex, age, race/ethnicity, socioeconomic status, and geographic locations.

Purpose of the Study:

To review and analyze lung cancer incidence and mortality patterns.
To examine global and United States-specific trends in lung cancer.
To understand the impact of historical smoking patterns on current lung cancer epidemiology.

Main Methods:

Review of existing epidemiological data on lung cancer incidence and mortality.
Analysis of trends stratified by demographic factors (sex, age, race/ethnicity, socioeconomic status).
Geographic mapping of lung cancer rates in the US and globally.

Main Results:

Lung cancer mortality rates are highest among males, Black individuals, those of lower socioeconomic status, and in the US Mid-South.
Globally, lung cancer rates are highest in regions with early smoking uptake (North America, Europe), though decreasing there.
Rates are increasing in low- and middle-income countries, which now represent over 50% of lung cancer deaths.

Conclusions:

Lung cancer epidemiology is complex and influenced by diverse factors, including smoking history and socioeconomic determinants.
Disparities in lung cancer burden necessitate targeted public health interventions.
Understanding geographic and demographic variations is crucial for effective lung cancer control strategies.