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Published on: March 3, 2020
Supercritical Fluid Technologies to Fabricate Proliposomes
James R Falconer1, Darren Svirskis, Ali A Adil
1School of Pharmacy, Pharmacy Australia Centre of Excellence, University of Queensland, Brisbane, QLD 4102, Australia. School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1010, New Zealand.
Supercritical fluid (SCF) technologies offer eco-friendly, single-step methods for preparing proliposomes, a stable drug carrier system. While challenges like scalability and complex processes exist, SCF methods show promise as an alternative to conventional fabrication techniques.
Area of Science:
- Pharmaceutical Technology
- Green Chemistry
- Materials Science
Background:
- Proliposomes are advanced drug delivery systems that form liposomes when hydrated.
- Conventional proliposome preparation methods face limitations in efficiency and environmental impact.
- Supercritical fluid (SCF) technologies present novel approaches to overcome these limitations.
Purpose of the Study:
- To review current trends in using supercritical fluid technologies for proliposome preparation.
- To compare SCF methods with conventional techniques for fabricating proliposomes.
- To identify advantages and challenges associated with SCF-based proliposome manufacturing.
Main Methods:
- Discussion of supercritical fluid (SCF) solvent and anti-solvent methods for proliposome fabrication.
- Analysis of SCF techniques in pharmaceutical research and industry.
- Comparison of particle morphology control offered by SCF versus conventional methods.
Main Results:
- SCF methods, particularly SCF solvent techniques, are eco-friendly and offer improved control over particle size and shape.
- SCF methods can provide a single-step process, contrasting with multi-step conventional approaches.
- Key challenges include poor scalability, potential variability in particle characteristics, and reliance on organic solvents in some SCF anti-solvent methods.
Conclusions:
- SCF technologies have the potential to be a viable alternative to conventional proliposome preparation methods.
- Further research is needed to address scalability, process complexity, and reproducibility of liposome formation and drug loading from proliposomes.
- Overcoming current hurdles could establish SCF methods as a superior green technology for advanced drug carrier systems.
