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Updated: Mar 28, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Hypothesis: Is frequent, commercial jet travel by the general public a risk factor for developing cutaneous melanoma?
1Department of Epidemiology and Environmental Health, University at Buffalo School of Public Health and Health Professions, Buffalo, NY, 14214-8001, USA ; Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA ; Department of Dermatology, Clinical and Translational Research Center, University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, 14203, USA.
Abstract:
Melanoma incidence has been increasing worldwide over the past 50 years and various risk factors have been identified. Interestingly, multiple studies have shown a multifold increased risk of developing melanoma in jet pilots and airline crew. There has also been a dramatic increase in the availability and frequency of jet travel by the general population during this time period.. Therefore, it is hypothesized that frequent commercial jet travel may represent an additional risk factor for the development of cutaneous melanoma in susceptible individuals of the general public.
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