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Clinical experience with ciprofloxacin.

J P Palmer, M C Barit, B Powderly

    The West Virginia Medical Journal
    |July 1, 1989
    PubMed
    Summary
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    Ciprofloxacin demonstrated high efficacy in treating various infections, achieving clinical cure or improvement in all 32 patients. Adverse reactions were infrequent, with nausea and dizziness noted in a small percentage of cases.

    Area of Science:

    • Infectious Diseases
    • Pharmacology

    Background:

    • Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic.
    • Bacterial infections require effective and safe therapeutic options.

    Purpose of the Study:

    • To evaluate the efficacy and safety of ciprofloxacin in treating a range of infections.
    • To assess clinical and bacteriologic outcomes and adverse drug reactions.

    Main Methods:

    • A multicenter study involving 32 patients with various infections.
    • Patients received ciprofloxacin with a mean daily dosage of 1,000 mg for a mean duration of 9.5 days.
    • Outcomes included microbiologic and clinical cure/improvement and adverse drug reactions (ADRs).

    Main Results:

    • Bacteriologic cure/improvement was achieved in all 8 microbiologically proved cases.

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  • Clinical cure/improvement was observed in all 32 infections treated.
  • Adverse drug reactions occurred in 9.4% of patients, with nausea and dizziness being the most common, leading to discontinuation in these cases.

    • Conclusions:

    • Ciprofloxacin is effective in achieving clinical and bacteriologic outcomes for various infections.
    • The drug was generally well-tolerated, with a low incidence of adverse drug reactions.
    • Nausea and dizziness were the primary adverse events, necessitating treatment cessation in affected individuals.