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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.9K
Notch Signaling Pathway03:14

Notch Signaling Pathway

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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

4.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Related Experiment Video

Updated: Mar 28, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

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[Neural stem cells and Notch signalling].

Elisabeth Traiffort1, Julien Ferent2

  • 1Inserm, Univ. Paris Sud, Université Paris-Saclay, laboratoire petites molécules de neuroprotection, neurorégénération et remyélinisation, U1195, 80, rue du Général Leclerc, F-94276 Le Kremlin-Bicêtre, France.

Medecine Sciences : M/S
|December 18, 2015
PubMed
Summary

Notch signaling is crucial for neural stem cell (NSC) development and repair in the nervous system. This pathway maintains NSC function from embryonic development through adulthood, impacting neurogenesis and regeneration.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Neural stem cells (NSCs) are essential for nervous system development and repair, generating neurons and glial cells.
  • The Notch signaling pathway is a key regulator of NSC behavior throughout life.

Purpose of the Study:

  • To elucidate the role of Notch signaling in the maintenance and function of embryonic and adult neural stem cells.
  • To understand Notch's contribution to neurogenesis, gliogenesis, and nervous system regeneration.

Main Methods:

  • Review of existing literature on Notch signaling and neural stem cells.
  • Analysis of Notch pathway involvement in central nervous system development.
  • Examination of Notch's role in postnatal and adult neurogenic niches and injury repair.

Main Results:

  • Notch signaling is vital for maintaining NSCs during embryonic central nervous system development, including neurogenesis and gliogenesis.
  • In adult neurogenic regions (subventricular zone and hippocampus), Notch signaling maintains NSC quiescence and cell heterogeneity.
  • The pathway exhibits pleiotropic effects in the regeneration processes following nervous system lesions.

Conclusions:

  • Notch signaling is a fundamental regulator of neural stem cell fate and function across all stages of nervous system development and repair.
  • Understanding Notch signaling in NSCs offers potential therapeutic targets for neurological disorders and injuries.