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Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
Published on: April 13, 2015
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[Subcutaneous panniculitis-like T-cell lymphoma : Two case reports]
1Klinik für Dermatologie, Allergologie und Phlebologie, Klinikum Bremerhaven Reinkenheide, Postbrookstr. 103, 27574, Bremerhaven, Deutschland. gunnar.wagner@klinikum-bremerhaven.de.
Summary
Subcutaneous panniculitis-like T-cell lymphoma, a rare condition, was diagnosed in two patients. Prompt treatment with radiotherapy and corticosteroids led to complete remission in both cases.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cytotoxic T-cell lymphoma.
- SPTCL typically involves the subcutaneous fat and can mimic other dermatological conditions.
- Accurate diagnosis relies on a combination of histopathology, immunohistochemistry, and molecular genetics.
Observation:
- Two patients, aged 44 and 70, were diagnosed with SPTCL.
- Clinical presentations varied significantly, from a solitary nodule to extensive plaques with atrophy.
- Neither patient presented with hemophagocytic syndrome.
Findings:
- Histopathology, immunohistochemical, and molecular genetic analyses confirmed SPTCL.
- The absence of hemophagocytic syndrome was noted in both cases.
- SPTCL without hemophagocytic syndrome is associated with a favorable prognosis.
Implications:
- Early diagnosis and appropriate treatment are crucial for favorable outcomes in SPTCL.
- Radiotherapy and systemic corticosteroids can effectively induce remission.
- This case series highlights the importance of considering SPTCL in patients with unusual cutaneous lesions.
