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Hydroxyapatite nanoparticles formed under a wet mechanochemical method.

Nudthakarn Kosachan1,2,3, Angkhana Jaroenworaluck3, Sirithan Jiemsirilers1,2

  • 1Research Unit for Advanced Ceramics, Science Faculty, Materials Science Department, Chulalongkorn University, Bangkok, 10330, Thailand.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|December 18, 2015
PubMed
Summary

Hydroxyapatite nanoparticles were synthesized using a wet mechanochemical method. Water as a liquid medium yielded low-crystallinity hydroxyapatite, unlike ethanol, which preserved starting materials.

Keywords:
calcium carbonate (CaCO3)dicalcium phosphate dihydrate (CaHPO4·2H2O)hydroxyapatitenanoparticleswet mechanochemical method

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Materials Chemistry

Background:

  • Hydroxyapatite (HA) is a crucial biomaterial for bone regeneration.
  • Conventional synthesis methods often involve high temperatures (calcination).
  • Developing low-temperature synthesis routes for HA nanoparticles is desirable.

Purpose of the Study:

  • To synthesize hydroxyapatite (HA) nanoparticles using a wet mechanochemical method without calcination.
  • To investigate the influence of liquid media (ethanol vs. water) on HA formation.
  • To optimize synthesis parameters like rotation speed and milling time.

Main Methods:

  • Wet mechanochemical synthesis using dicalcium phosphate dihydrate and calcium carbonate.
  • Planetary ball milling with ethanol or water as liquid media.
  • Analysis of phase formation, particle size, and morphology under varying milling conditions.

Main Results:

  • Hydroxyapatite (HA) phase with low crystallinity was successfully formed using water as the liquid medium.
  • Ethanol as a liquid medium resulted in the retention of starting materials without HA formation.
  • Particle size and morphology of HA nanoparticles were significantly influenced by rotation speed and milling time.

Conclusions:

  • Wet mechanochemical synthesis offers a viable, low-temperature route for HA nanoparticle production.
  • The choice of liquid medium critically affects phase formation during mechanochemical synthesis.
  • Optimized milling parameters are essential for controlling HA nanoparticle characteristics.